| Gene Information | |
|---|---|
| Gene Name | AQP9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 342 |
| Protein Names | Aquaporin-7 (AQP-7) (Aquaglyceroporin-7) (Aquaporin adipose) (AQPap) (Aquaporin-7-like) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000103569 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O14520 |
| Gene Card | AQP7 |
| Uniprot ID | O14520 |
| Pfam | PF00230 |
| In ASD | no |
| Allosteric Prediction | no (-0.038780792) |
| Ortholog in Animals | Alpaca_ AQP9 ( ortholog_one2one ) Dog_ AQP9 ( ortholog_one2one ) GuineaPig_ AQP9 ( ortholog_one2one ) Macaque_ AQP9 ( ortholog_one2one ) Mouse_ Aqp9 ( ortholog_one2one ) Pig_ AQP9 ( ortholog_one2one ) Rat_ Aqp9 ( ortholog_one2one ) Rabbit_ AQP9 ( ortholog_one2one ) |
| Ohnologs | AQP10, AQP3 |
| Paralogs | MIP, AQP3, AQP1, AQP5, AQP4, AQP6, AQP10, AQP8, AQP7B, AQP7, AQP2 |
| Tissue | liver, lung, spleen, whole.blood |
| Tissue Specificity | Detected in the sperm head (at protein level) (PubMed:28042826). Detected in white adipose tissue (PubMed:9405233). {ECO:0000269|PubMed:28042826, ECO:0000269|PubMed:9405233}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 6KXW (X-ray 3.70A ) 6N1G (X-ray 4.00A ) 6QZI (X-ray 1.90A ) 6QZJ (X-ray 2.20A ) |
| DBSNP | rs139297434 rs2381003 rs4008659 rs4008658 rs62542743 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:11952783, ECO:0000269|PubMed:28042826, ECO:0000269|PubMed:30423801, ECO:0000269|PubMed:9405233}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O54794}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:27832861}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Lipid droplet {ECO:0000305|PubMed:27832861}. Note=Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (By similarity). Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (PubMed:27832861). {ECO:0000250|UniProtKB:O54794, ECO:0000269|PubMed:27832861}. |
| Mouse PG classification | NA |
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