| Gene Information | |
|---|---|
| Gene Name | PLCG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1265 |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000197943 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P16885 |
| Gene Card | PLCG2 |
| Uniprot ID | P16885 |
| Pfam | PF00168; PF00388; PF00387; PF00017; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.912436362) |
| Ortholog in Animals | Alpaca_ PLCG2 ( ortholog_one2one ) Dog_ PLCG2 ( ortholog_one2one ) GuineaPig_ PLCG2 ( ortholog_one2one ) Macaque_ PLCG2 ( ortholog_one2one ) Mouse_ Plcg2 ( ortholog_one2one ) Pig_ PLCG2 ( ortholog_one2one ) Rat_ Plcg2 ( ortholog_one2one ) Rabbit_ PLCG2 ( ortholog_one2one ) |
| Ohnologs | PLCG1 |
| Paralogs | PLCD3, PLCB3, PLCE1, PLCG1, PLCB1, PLCD4, PLCD1, PLCB2, PLCB4, PLCL2, PLCH1, PLCL1, PLCZ1, PLCH2 |
| Tissue | spleen, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.017647(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K2J (NMR - ) 2W2W (X-ray 2.80A ) 2W2X (X-ray 2.30A ) |
| DBSNP | rs11548656 rs1143687 rs11548657 rs1057519831 rs397514562 rs1057519832 rs17856213 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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