Gene Information
Gene NameARF6
OrganismHomo sapiens (Human)
Gene Length175
Protein NamesADP-ribosylation factor 6 (EC 3.6.5.2)
Target Nameadp-ribosylation factor 6
Target TypeNA
Gene Age1292 ( ENSG00000165527 )
Evolutionary StageOpisthokonta
AlphaFoldDBP62330
Gene CardARF6
Uniprot IDP62330
PfamPF00025
In ASDyes
Allosteric Predictionyes (0.821192326)
Ortholog in AnimalsAlpaca_ ARF6 ( ortholog_one2one )
Dog_ ARF6 ( ortholog_one2one )
GuineaPig_ ARF6 ( ortholog_one2one )
Macaque_ ARF6 ( ortholog_one2one )
Mouse_ Arf6 ( ortholog_one2one )
Pig_ ARF6 ( ortholog_one2one )
Rat_ Arf6 ( ortholog_one2one )
Rabbit_ ARF6 ( ortholog_one2one )
OhnologsNA
ParalogsARL5C, ARF4, ARL10, ARL16, ARL2, ARFRP1, ARL17B, ARL17A, ARF3, ARF1, ARL1, ARL8B, TRIM23, ARL4D, ARL9, ARL14, ARL4A, ARL6, ARL13B, ARL13A, ARL15, ARL11, ARL5A, ARF5, ARL3, ARL8A, SAR1B, ARL4C, ARL5B, SAR1A
TissueNA
Tissue SpecificityUbiquitous, with higher levels in heart, substantia nigra, and kidney. {ECO:0000269|PubMed:14659046}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.009091(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1E0S  (X-ray  2.28A  )  2A5D  (X-ray  1.80A  )  2A5F  (X-ray  2.02A  )  2A5G  (X-ray  2.66A  )  2BAO  (NMR  -  )  2BAU  (NMR  -  )  2J5X  (X-ray  2.80A  )  2W83  (X-ray  1.93A  )  3LVQ  (X-ray  3.38A  )  3LVR  (X-ray  3.38A  )  3N5C  (X-ray  1.82A  )  3PCR  (X-ray  2.50A  )  4FME  (X-ray  4.10A  )  4KAX  (X-ray  1.85A  )  6BBP  (EM  35.00A  )  6BBQ  (EM  35.00A  )  6PAU  (X-ray  1.93A  )  7RK3  (X-ray  2.05A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:23603394, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Cell membrane {ECO:0000269|PubMed:16737952, ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:17555535, ECO:0000269|PubMed:32103017};
Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Endosome membrane {ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20682791, ECO:0000269|PubMed:21951725};
Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Recycling endosome membrane {ECO:0000269|PubMed:21951725};
Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216};
Lipid-anchor {ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}. Cell projection, ruffle {ECO:0000269|PubMed:16737952}. Cleavage furrow {ECO:0000269|PubMed:23603394}. Midbody, Midbody ring {ECO:0000269|PubMed:23603394}. Early endosome membrane {ECO:0000250|UniProtKB:P62331};
Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P62331};
Lipid-anchor {ECO:0000250|UniProtKB:P62331}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In late stages of cytokinesis, concentrates at the midbody ring/Flemming body (PubMed:23603394). Recruitment to the midbody ring requires both activation by PSD/EFA6A and interaction with KIF23/MKLP1 (PubMed:23603394). After abscission of the intercellular bridge, incorporated into one of the daughter cells as a midbody remnant and localizes to punctate structures beneath the plasma membrane (PubMed:23603394). Recruited to the cell membrane in association with CYTH2 and ARL4C (PubMed:17398095). Colocalizes with DAB2IP at the plasma membrane and endocytic vesicles (PubMed:19948740). Myristoylation is required for proper localization to membranes: myristoylation on Lys-3 allows ARF6 to remain on membranes during the GTPase cycle (PubMed:7589240, PubMed:32103017). {ECO:0000269|PubMed:17398095, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:23603394, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:7589240}.
Mouse PG classificationNA
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