| Gene Information | |
|---|---|
| Gene Name | ARC |
| Organism | Homo sapiens (Human) |
| Gene Length | 208 |
| Protein Names | Nucleolar protein 3 (Apoptosis repressor with CARD) (Muscle-enriched cytoplasmic protein) (Myp) (Nucleolar protein of 30 kDa) (Nop30) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000198576 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O60936 |
| Gene Card | NOL3 |
| Uniprot ID | O60936 |
| Pfam | PF00619 |
| In ASD | no |
| Allosteric Prediction | no (-0.46094987) |
| Ortholog in Animals | Alpaca_ ARC ( ortholog_one2one ) Dog_ ARC ( ortholog_one2one ) GuineaPig_ ARC ( ortholog_one2one ) Macaque_ ARC ( ortholog_one2many ) Mouse_ Arc ( ortholog_one2one ) Pig_ ARC ( ortholog_one2one ) Rat_ Arc ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | pituitary.gland |
| Tissue Specificity | Highly expressed in heart and skeletal muscle. Detected at low levels in placenta, liver, kidney and pancreas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UZ0 (X-ray 2.40A ) |
| DBSNP | rs397514600 rs780601409 |
| Subcellular location [CC] | [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:10196175}. Note=The SR-rich C-terminus mediates nuclear localization. {ECO:0000269|PubMed:10196175}.; [Isoform 3]: Cytoplasm {ECO:0000305}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10196175}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}. |
| Mouse PG classification | NA |
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