| Gene Information | |
|---|---|
| Gene Name | ARAP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1450 |
| Protein Names | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000186635 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q96P48 |
| Gene Card | ARAP1 |
| Uniprot ID | Q96P48 |
| Pfam | PF01412; PF00169; PF00788; PF00620; PF00536 |
| In ASD | no |
| Allosteric Prediction | yes (0.325090052) |
| Ortholog in Animals | Alpaca_ ARAP1 ( ortholog_one2one ) Dog_ ARAP1 ( ortholog_one2one ) GuineaPig_ ARAP1 ( ortholog_one2one ) Macaque_ ARAP1 ( ortholog_one2one ) Mouse_ Arap1 ( ortholog_one2one ) Pig_ ARAP1 ( ortholog_one2one ) Rat_ Arap1 ( ortholog_one2one ) |
| Ohnologs | ARAP2, ARAP3 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | Detected in heart, skeletal muscle, spleen, kidney, liver, placenta, lung, peripheral blood leukocytes, adrenal gland, bone marrow, brain, lymph node, mammary gland, prostate, spinal cord, stomach, thyroid and trachea. {ECO:0000269|PubMed:11804590}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4X1V (X-ray 1.58A ) |
| DBSNP | rs34976830 rs56200889 |
| Subcellular location [CC] | Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane. Note=Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading. |
| Mouse PG classification | NA |
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