| Gene Information | |
|---|---|
| Gene Name | NAT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 487 |
| Protein Names | Sodium-coupled neutral amino acid symporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 25 ( ENSG00000156006 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9H2H9 |
| Gene Card | SLC38A1 |
| Uniprot ID | Q9H2H9 |
| Pfam | PF01490 |
| In ASD | no |
| Allosteric Prediction | yes (0.682999825) |
| Ortholog in Animals | Alpaca_ NAT2 ( ortholog_one2one ) Macaque_ NAT2 ( ortholog_one2one ) Mouse_ Nat1 ( ortholog_many2many ) Mouse_ Nat3 ( ortholog_many2many ) Mouse_ Nat2 ( ortholog_many2many ) Rat_ Nat1 ( ortholog_many2many ) Rat_ Nat3 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | NAT1 |
| Tissue | duodenum, liver, small.intestine, kidney, sigmoid.colon, spleen |
| Tissue Specificity | Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis (PubMed:10891391, PubMed:12388062, PubMed:15054072, PubMed:16148032). Highly expressed in cytotrophoblast cells from term placenta (PubMed:20599747). {ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:15054072, ECO:0000269|PubMed:16148032, ECO:0000269|PubMed:20599747}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}. |
| Mouse PG classification | NA |
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