| Gene Information | |
|---|---|
| Gene Name | AQP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 323 |
| Protein Names | Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171885 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P55087 |
| Gene Card | AQP4 |
| Uniprot ID | P55087 |
| Pfam | PF00230 |
| In ASD | no |
| Allosteric Prediction | yes (0.262328164) |
| Ortholog in Animals | Alpaca_ AQP4 ( ortholog_one2one ) Dog_ AQP4 ( ortholog_one2one ) GuineaPig_ AQP4 ( ortholog_one2one ) Macaque_ AQP4 ( ortholog_one2one ) Mouse_ Aqp4 ( ortholog_one2one ) Pig_ AQP4 ( ortholog_one2one ) Rat_ Aqp4 ( ortholog_one2one ) Rabbit_ AQP4 ( ortholog_one2one ) |
| Ohnologs | AQP6, MINDY4, MIP, AQP5, AQP2 |
| Paralogs | MIP, AQP3, AQP1, AQP5, AQP6, AQP10, AQP8, AQP7B, AQP7, AQP9, AQP2 |
| Tissue | brain, cerebral.cortex, lung |
| Tissue Specificity | Detected in skeletal muscle (PubMed:29055082). Detected in stomach, along the glandular base region of the fundic gland (at protein level) (PubMed:8601457). Detected in brain, lung and skeletal muscle, and at much lower levels in heart and ovary (PubMed:7559426, PubMed:8601457). {ECO:0000269|PubMed:29055082, ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3GD8 (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:7559426, ECO:0000269|PubMed:8601457}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Basolateral cell membrane {ECO:0000250|UniProtKB:P55088}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma {ECO:0000269|PubMed:29055082}; Multi-pass membrane protein {ECO:0000269|PubMed:19383790}. Cell projection {ECO:0000250|UniProtKB:P47863}. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. {ECO:0000250|UniProtKB:P47863}. |
| Mouse PG classification | NA |
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