| Gene Information | |
|---|---|
| Gene Name | AQP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 271 |
| Protein Names | Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000167580 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P41181 |
| Gene Card | AQP2 |
| Uniprot ID | P41181 |
| Pfam | PF00230 |
| In ASD | no |
| Allosteric Prediction | no (-0.034240327) |
| Ortholog in Animals | Alpaca_ AQP2 ( ortholog_one2one ) Dog_ AQP2 ( ortholog_one2one ) GuineaPig_ AQP2 ( ortholog_one2one ) Macaque_ AQP2 ( ortholog_one2one ) Mouse_ Aqp2 ( ortholog_one2one ) Pig_ AQP2 ( ortholog_one2one ) Rat_ Aqp2 ( ortholog_one2one ) Rabbit_ AQP2 ( ortholog_one2one ) |
| Ohnologs | AQP4, MINDY4, MIP |
| Paralogs | MIP, AQP3, AQP1, AQP5, AQP4, AQP6, AQP10, AQP8, AQP7B, AQP7, AQP9 |
| Tissue | kidney, seminal.vesicle, vas.deferens, cortex.of.kidney |
| Tissue Specificity | Expressed in collecting tubules in kidney medulla (at protein level) (PubMed:7510718). Detected in kidney (PubMed:7510718). {ECO:0000269|PubMed:7510718}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4NEF (X-ray 2.75A ) 4OJ2 (X-ray 3.05A ) 6QF5 (X-ray 3.70A ) |
| DBSNP | rs104894336 rs995684800 rs28931580 rs104894326 rs104894331 rs149659001 rs1303076207 rs104894338 rs1468828294 rs11169226 rs104894333 rs104894330 rs104894334 rs755694590 rs104894335 rs147039983 rs104894337 rs761713751 rs104894328 rs193922495 rs104894341 rs772051028 rs104894329 rs104894332 rs104894339 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:15509592, ECO:0000269|PubMed:7510718}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:24733887}. Basolateral cell membrane {ECO:0000250|UniProtKB:P34080}; Multi-pass membrane protein {ECO:0000269|PubMed:24733887}. Cell membrane {ECO:0000269|PubMed:15509592, ECO:0000269|PubMed:24733887, ECO:0000269|PubMed:7524315, ECO:0000269|PubMed:8140421}; Multi-pass membrane protein {ECO:0000269|PubMed:24733887}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:15509592}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:24733887}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:12194985}; Multi-pass membrane protein {ECO:0000269|PubMed:12194985, ECO:0000269|PubMed:24733887}. Note=Shuttles from vesicles to the apical membrane (PubMed:15509592). Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane (PubMed:15509592). PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated (By similarity). {ECO:0000250|UniProtKB:P34080, ECO:0000269|PubMed:15509592}. |
| Mouse PG classification | NA |
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