| Gene Information | |
|---|---|
| Gene Name | APPL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 664 |
| Protein Names | DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000136044 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q8NEU8 |
| Gene Card | APPL2 |
| Uniprot ID | Q8NEU8 |
| Pfam | PF00169; PF00640 |
| In ASD | no |
| Allosteric Prediction | no (-1.143250471) |
| Ortholog in Animals | Alpaca_ APPL2 ( ortholog_one2one ) Dog_ APPL2 ( ortholog_one2one ) GuineaPig_ APPL2 ( ortholog_one2one ) Macaque_ APPL2 ( ortholog_one2one ) Mouse_ Appl2 ( ortholog_one2one ) Pig_ APPL2 ( ortholog_one2one ) Rat_ Appl2 ( ortholog_one2one ) Rabbit_ APPL2 ( ortholog_one2one ) |
| Ohnologs | APPL1 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | High levels in brain, heart, kidney and skeletal muscle. {ECO:0000269|PubMed:11431708}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4H8S (X-ray 3.50A ) 5C5B (X-ray 2.90A ) |
| DBSNP | rs2272495 |
| Subcellular location [CC] | Early endosome membrane {ECO:0000269|PubMed:15016378}; Peripheral membrane protein {ECO:0000269|PubMed:15016378}. Nucleus {ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:18034774}. Cell membrane {ECO:0000269|PubMed:18034774}. Endosome membrane {ECO:0000269|PubMed:21645192}. Cytoplasm {ECO:0000250|UniProtKB:Q8K3G9}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8K3G9}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8K3G9}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8K3G9}. Cell membrane {ECO:0000250|UniProtKB:Q8K3G9}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8K3G9}. Note=Early endosomal membrane-bound and nuclear (PubMed:15016378). Translocated into the nucleus upon release from endosomal membranes following internalization of EGF (PubMed:15016378). Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events (PubMed:18034774). PI(4,5)P2 levels are important for membrane association of APPL2 (PubMed:18034774). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome (By similarity). Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:18034774}. |
| Mouse PG classification | NA |
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