| Gene Information | |
|---|---|
| Gene Name | APPL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000136044 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q06481 |
| Gene Card | APLP2 |
| Uniprot ID | Q06481 |
| Pfam | PF10515; PF12924; PF12925; PF02177; PF00014 |
| In ASD | no |
| Allosteric Prediction | no (-1.143250471) |
| Ortholog in Animals | Alpaca_ APPL2 ( ortholog_one2one ) Dog_ APPL2 ( ortholog_one2one ) GuineaPig_ APPL2 ( ortholog_one2one ) Macaque_ APPL2 ( ortholog_one2one ) Mouse_ Appl2 ( ortholog_one2one ) Pig_ APPL2 ( ortholog_one2one ) Rat_ Appl2 ( ortholog_one2one ) Rabbit_ APPL2 ( ortholog_one2one ) |
| Ohnologs | APPL1 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, ARFGAP3, GIT2, ADAP2, SMAP2, AGAP2, ACAP1 |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001615(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5JBT (X-ray 1.40A ) 5TPT (X-ray 2.42A ) |
| DBSNP | rs3740881 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |