| Gene Information | |
|---|---|
| Gene Name | APOO |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | MICOS complex subunit MIC26 (Apolipoprotein O) (MICOS complex subunit MIC23) (Protein FAM121B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000184831 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BUR5 |
| Gene Card | APOO |
| Uniprot ID | Q9BUR5 |
| Pfam | PF09769 |
| In ASD | no |
| Allosteric Prediction | no (-0.739918183) |
| Ortholog in Animals | Alpaca_ APOO ( ortholog_one2one ) Dog_ APOO ( ortholog_one2many ) Macaque_ APOO ( ortholog_one2one ) Mouse_ Apoo ( ortholog_one2one ) Pig_ APOO ( ortholog_one2one ) Rat_ Apoo ( ortholog_one2many ) |
| Ohnologs | APOOL |
| Paralogs | APOOL |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined. Up-regulated in diabetic heart. {ECO:0000269|PubMed:16956892}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001823(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000269|PubMed:25764979}; Single-pass membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:16956892, ECO:0000269|PubMed:25764979}. Mitochondrion {ECO:0000269|PubMed:25781180}. Golgi apparatus membrane {ECO:0000269|PubMed:25764979}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25764979}. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000269|PubMed:25764979}. |
| Mouse PG classification | NA |
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