| Gene Information | |
|---|---|
| Gene Name | ALKBH8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 664 |
| Protein Names | Alkylated DNA repair protein alkB homolog 8 (Probable alpha-ketoglutarate-dependent dioxygenase ABH8) (S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8) (tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8) (EC 2.1.1.229) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000137760 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96BT7 |
| Gene Card | ALKBH8 |
| Uniprot ID | Q96BT7 |
| Pfam | PF13532; PF09004; PF08241 |
| In ASD | no |
| Allosteric Prediction | no (-1.070171877) |
| Ortholog in Animals | Alpaca_ ALKBH8 ( ortholog_one2one ) Dog_ ALKBH8 ( ortholog_one2one ) Macaque_ ALKBH8 ( ortholog_one2one ) Mouse_ Alkbh8 ( ortholog_one2one ) Pig_ ALKBH8 ( ortholog_one2one ) Rat_ Alkbh8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRMT9B, ALKBH6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest expression in spleen, followed by pancreas and lung. {ECO:0000269|PubMed:17979886}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CQ2 (NMR - ) 3THP (X-ray 3.20A ) 3THT (X-ray 3.01A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:34948388}. Nucleus {ECO:0000269|PubMed:20308323}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:20308323}. |
| Mouse PG classification | NA |
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