| Gene Information | |
|---|---|
| Gene Name | APOL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I) |
| Target Name | apolipoprotein l1 |
| Target Type | NA |
| Gene Age | 12 ( ENSG00000100342 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14791 |
| Gene Card | APOL1 |
| Uniprot ID | O14791 |
| Pfam | PF05461 |
| In ASD | no |
| Allosteric Prediction | yes (0.337797156) |
| Ortholog in Animals | Mouse_ Apol7a ( ortholog_many2many ) Mouse_ Apol7c ( ortholog_many2many ) Mouse_ Apol11a ( ortholog_many2many ) Mouse_ Apol8 ( ortholog_many2many ) Mouse_ Apol7e ( ortholog_many2many ) Mouse_ Apol7b ( ortholog_many2many ) Mouse_ Apol11b ( ortholog_many2many ) Mouse_ Apol10a ( ortholog_many2many ) Mouse_ Apol9a ( ortholog_many2many ) Mouse_ Apol9b ( ortholog_many2many ) Mouse_ Apol10b ( ortholog_many2many ) Rat_ Apol3 ( ortholog_many2many ) Rat_ AABR07058464.1 ( ortholog_many2many ) Rat_ AABR07058479.1 ( ortholog_many2many ) Rat_ Apol2 ( ortholog_many2many ) Rat_ RGD1309808 ( ortholog_many2many ) Rat_ Apol9a ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | APOL2, APOL3, APOL4, APOL6, APOL5, APOLD1 |
| Tissue | NA |
| Tissue Specificity | Plasma. Found on APOA-I-containing high density lipoprotein (HDL3). Expressed in pancreas, lung, prostate, liver, placenta and spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7L6K (NMR - ) 7LF7 (X-ray 2.03A ) 7LFA (X-ray 1.86A ) 7LFB (X-ray 1.91A ) 7LFD (X-ray 2.16A ) |
| DBSNP | rs2239785 rs136175 rs136176 rs16996616 rs73885319 rs60910145 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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