Gene Information
Gene NameCRHR1
OrganismHomo sapiens (Human)
Gene Length444
Protein NamesCorticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1)
Target Namecorticotropin-releasing factor receptor 1
Target TypeSuccessful target
Gene Age544 ( ENSG00000120088 )
3 ( ENSG00000276191 )
3 ( ENSG00000278232 )
Evolutionary StageEumetazoa
AlphaFoldDBP34998
Gene CardCRHR1
Uniprot IDP34998
PfamPF00002; PF02793
In ASDyes
Allosteric Predictionyes (1.583811389)
Ortholog in AnimalsAlpaca_ CRHR1 ( ortholog_one2many )
Dog_ CRHR1 ( ortholog_one2one )
GuineaPig_ CRHR1 ( ortholog_one2one )
Macaque_ CRHR1 ( ortholog_one2one )
Mouse_ Crhr1 ( ortholog_one2one )
Pig_ CRHR1 ( ortholog_one2one )
Rat_ Crhr1 ( ortholog_one2one )
Rabbit_ CRHR1 ( ortholog_one2one )
OhnologsVIPR2, CRHR2, VIPR1
ParalogsADGRE3, ADGRL2, VIPR1, ADGRL4, ADGRE2, ADGRG4, ADGRD1, ADGRL3, GHRHR, PTH2R, ADGRE1, ADGRD2, ADGRL1, ADGRB3, EVA1C, ADGRG1, SCTR, ADGRF5, ADGRA3, GLP2R, PTH1R, CALCR, ADGRF3, GIPR, ADGRA1, ADGRF1, ADCYAP1R1, ADGRG5, ADGRE5, CRHR2, ADGRB2, ADGRG6, GCGR, ADGRB1, ADGRG2, ADGRA2, ADGRF4, VIPR2, ADGRG7, CALCRL, ADGRG3, GLP1R
Tissuecerebellar.hemisphere, cerebellum
Tissue SpecificityPredominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. {ECO:0000269|PubMed:8243652}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.003990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2L27  (NMR  -  )  3EHS  (X-ray  2.76A  )  3EHT  (X-ray  3.40A  )  3EHU  (X-ray  1.96A  )  4K5Y  (X-ray  2.98A  )  4Z9G  (X-ray  3.18A  )  6P9X  (EM  2.91A  )  6PB0  (EM  3.00A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane;
Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis.
Mouse PG classificationNA
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