| Gene Information | |
|---|---|
| Gene Name | APOE |
| Organism | Homo sapiens (Human) |
| Gene Length | 317 |
| Protein Names | Apolipoprotein E (Apo-E) |
| Target Name | apolipoprotein e |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000130203 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02649 |
| Gene Card | APOE |
| Uniprot ID | P02649 |
| Pfam | PF01442 |
| In ASD | yes |
| Allosteric Prediction | yes (1.239530153) |
| Ortholog in Animals | Alpaca_ APOE ( ortholog_one2one ) Dog_ APOE ( ortholog_one2one ) GuineaPig_ APOE ( ortholog_one2one ) Macaque_ APOE ( ortholog_one2one ) Mouse_ Apoe ( ortholog_one2one ) Pig_ APOE ( ortholog_one2one ) Rat_ Apoe ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | APOA5, APOA4, APOA1 |
| Tissue | NA |
| Tissue Specificity | Produced by several tissues and cell types and mainly found associated with lipid particles in the plasma, the interstitial fluid and lymph (PubMed:25173806). Mainly synthesized by liver hepatocytes (PubMed:25173806). Significant quantities are also produced in brain, mainly by astrocytes and glial cells in the cerebral cortex, but also by neurons in frontal cortex and hippocampus (PubMed:3115992, PubMed:10027417). It is also expressed by cells of the peripheral nervous system (PubMed:10027417, PubMed:25173806). Also expressed by adrenal gland, testis, ovary, skin, kidney, spleen and adipose tissue and macrophages in various tissues (PubMed:25173806). {ECO:0000269|PubMed:10027417, ECO:0000269|PubMed:3115992, ECO:0000303|PubMed:25173806}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1B68 (X-ray 2.00A ) 1BZ4 (X-ray 1.85A ) 1EA8 (X-ray 1.95A ) 1GS9 (X-ray 1.70A ) 1H7I (X-ray 1.90A ) 1LE2 (X-ray 3.00A ) 1LE4 (X-ray 2.50A ) 1LPE (X-ray 2.25A ) 1NFN (X-ray 1.80A ) 1NFO (X-ray 2.00A ) 1OEF (NMR - ) 1OEG (NMR - ) 1OR2 (X-ray 2.50A ) 1OR3 (X-ray 1.73A ) 2KC3 (NMR - ) 2KNY (NMR - ) 2L7B (NMR - ) 6IWB (X-ray 2.50A ) 6NCN (X-ray 1.82A ) 6NCO (X-ray 1.71A ) 7FCR (X-ray 1.40A ) 7FCS (X-ray 1.60A ) |
| DBSNP | rs121918392 rs201672011 rs121918399 rs769452 rs28931576 rs370594287 rs1180612218 rs11083750 rs28931577 rs937063425 rs429358 rs267606664 rs28931578 rs121918393 rs121918393 rs387906567 rs769455 rs121918397 rs121918397 rs121918394 rs121918394 rs267606662 rs7412 rs267606663 rs121918395 rs199768005 rs267606661 rs121918398 rs28931579 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:2498325, ECO:0000269|PubMed:30333625}. Secreted, extracellular space {ECO:0000269|PubMed:8340399}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:9488694}. Extracellular vesicle {ECO:0000269|PubMed:26387950}. Endosome, multivesicular body {ECO:0000269|PubMed:26387950}. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins (PubMed:1911868, PubMed:8340399). Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner (PubMed:9488694). Lipidation induces the release from the extracellular matrix (PubMed:9488694). Colocalizes with CD63 and PMEL at exosomes and in intraluminal vesicles within multivesicular endosomes. {ECO:0000269|PubMed:1911868, ECO:0000269|PubMed:26387950, ECO:0000269|PubMed:8340399, ECO:0000269|PubMed:9488694}. |
| Mouse PG classification | NA |
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