| Gene Information | |
|---|---|
| Gene Name | APOBEC3G |
| Organism | Homo sapiens (Human) |
| Gene Length | 384 |
| Protein Names | DNA dC->dU-editing enzyme APOBEC-3G (EC 3.5.4.38) (APOBEC-related cytidine deaminase) (APOBEC-related protein) (ARCD) (APOBEC-related protein 9) (ARP-9) (CEM-15) (CEM15) (Deoxycytidine deaminase) (A3G) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000239713 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9HC16 |
| Gene Card | APOBEC3G |
| Uniprot ID | Q9HC16 |
| Pfam | NA |
| In ASD | yes |
| Allosteric Prediction | yes (0.639130296) |
| Ortholog in Animals | Alpaca_ APOBEC3G ( ortholog_one2one ) Dog_ APOBEC3Z1 ( ortholog_one2many ) Macaque_ APOBEC3G ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | APOBEC3B, APOBEC3A, APOBEC2, APOBEC3H, APOBEC3C, APOBEC3F, APOBEC3D, AICDA, APOBEC1 |
| Tissue | NA |
| Tissue Specificity | Expressed in spleen, testes, ovary and peripheral blood leukocytes and CD4+ lymphocytes. Also expressed in non-permissive peripheral blood mononuclear cells, and several tumor cell lines; no expression detected in permissive lymphoid and non-lymphoid cell lines. Exists only in the LMM form in peripheral blood-derived resting CD4 T-cells and monocytes, both of which are refractory to HIV-1 infection. LMM is converted to a HMM complex when resting CD4 T-cells are activated or when monocytes are induced to differentiate into macrophages. This change correlates with increased susceptibility of these cells to HIV-1 infection. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:12167863, ECO:0000269|PubMed:20308164}. |
| Pharmacological Animal Models | 0.014105(Chimpanzee);NULL(Mouse);NULL(Rat);0.084615(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2JYW (NMR - ) 2KBO (NMR - ) 2KEM (NMR - ) 3E1U (X-ray 2.30A ) 3IQS (X-ray 2.30A ) 3IR2 (X-ray 2.25A ) 3V4J (X-ray 2.04A ) 3V4K (X-ray 1.38A ) 4ROV (X-ray 1.80A ) 4ROW (X-ray 1.70A ) 5ZVA (X-ray 2.30A ) 5ZVB (X-ray 2.00A ) 6BUX (X-ray 1.86A ) 6BWY (X-ray 2.90A ) 6K3J (NMR - ) 6K3K (NMR - ) |
| DBSNP | rs8177832 rs17000736 rs17496046 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Mainly cytoplasmic. Small amount are found in the nucleus. During HIV-1 infection, virion-encapsidated in absence of HIV-1 Vif. |
| Mouse PG classification | NA |
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