| Gene Information | |
|---|---|
| Gene Name | APOBEC3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 382 |
| Protein Names | DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 70 ( ENSG00000179750 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9UH17 |
| Gene Card | APOBEC3B |
| Uniprot ID | Q9UH17 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.555247866) |
| Ortholog in Animals | Alpaca_ APOBEC3B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | APOBEC2, APOBEC3H, APOBEC3C, APOBEC3F, APOBEC3D, APOBEC3G, AICDA, APOBEC1, APOBEC3A |
| Tissue | bone.marrow, rectum |
| Tissue Specificity | Expressed at high and moderate levels in peripheral blood leukocytes, spleen, testes, heart, thymus, prostate and ovary. Also expressed at low levels in several other tissues. {ECO:0000269|PubMed:11863358, ECO:0000269|PubMed:20308164}. |
| Pharmacological Animal Models | 0.014105(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NBQ (NMR - ) 5CQD (X-ray 2.08A ) 5CQH (X-ray 1.73A ) 5CQI (X-ray 1.68A ) 5CQK (X-ray 1.88A ) 5SXG (X-ray 1.93A ) 5SXH (X-ray 1.78A ) 5TD5 (X-ray 1.72A ) 5TKM (X-ray 1.90A ) 6NFK (X-ray 1.86A ) 6NFL (X-ray 1.73A ) 6NFM (X-ray 2.53A ) 7RW6 (EM 2.55A ) |
| DBSNP | rs2076109 rs2076110 rs17000697 rs5995649 rs1053813 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16699599, ECO:0000269|PubMed:18667511, ECO:0000269|PubMed:21835787, ECO:0000269|PubMed:22915799}. |
| Mouse PG classification | NA |
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