| Gene Information | |
|---|---|
| Gene Name | AGAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1192 |
| Protein Names | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (GTP-binding and GTPase-activating protein 2) (GGAP2) (Phosphatidylinositol 3-kinase enhancer) (PIKE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000135439 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99490 |
| Gene Card | AGAP2 |
| Uniprot ID | Q99490 |
| Pfam | PF12796; PF01412; PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.376385498) |
| Ortholog in Animals | Alpaca_ AGAP2 ( ortholog_one2one ) Dog_ AGAP2 ( ortholog_one2one ) GuineaPig_ AGAP2 ( ortholog_one2one ) Macaque_ AGAP2 ( ortholog_one2one ) Mouse_ Agap2 ( ortholog_one2one ) Pig_ AGAP2 ( ortholog_one2one ) Rat_ Agap2 ( ortholog_one2one ) Rabbit_ AGAP2 ( ortholog_one2one ) |
| Ohnologs | AGAP3, AGAP1 |
| Paralogs | ASAP2, ASAP1, ACAP3, ARAP2, GIT1, ARAP3, AGFG1, ADAP1, SMAP1, AGAP1, ACAP2, AGAP3, AGAP4, AGAP6, AGAP9, AGAP5, ARFGAP1, ASAP3, APPL1, ARFGAP2, ARAP1, AGFG2, APPL2, ARFGAP3, GIT2, ADAP2, SMAP2, ACAP1 |
| Tissue | cerebral.cortex |
| Tissue Specificity | Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295, ECO:0000269|PubMed:16150119}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2BMJ (X-ray 2.10A ) 2IWR (X-ray 1.50A ) 2RLO (NMR - ) |
| DBSNP | rs2301553 rs238521 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. |
| Mouse PG classification | NA |
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