| Gene Information | |
|---|---|
| Gene Name | APOA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 267 |
| Protein Names | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I (Apolipoprotein A-I(1-242))] |
| Target Name | apolipoprotein a-i |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000118137 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P02647 |
| Gene Card | APOA1 |
| Uniprot ID | P02647 |
| Pfam | PF01442 |
| In ASD | no |
| Allosteric Prediction | yes (1.026277364) |
| Ortholog in Animals | Alpaca_ APOA1 ( ortholog_one2many ) Dog_ APOA1 ( ortholog_one2one ) GuineaPig_ APOA1 ( ortholog_one2one ) Macaque_ APOA1 ( ortholog_one2one ) Mouse_ Apoa1 ( ortholog_one2one ) Pig_ APOA1 ( ortholog_one2one ) Rat_ Apoa1 ( ortholog_one2one ) Rabbit_ APOA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | APOA4, APOE, APOA5 |
| Tissue | liver, small.intestine, brain, testis |
| Tissue Specificity | Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. {ECO:0000269|PubMed:12576517}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1AV1 (X-ray 4.00A ) 1GW3 (NMR - ) 1GW4 (NMR - ) 1ODP (NMR - ) 1ODQ (NMR - ) 1ODR (NMR - ) 2MSC (NMR - ) 2MSD (NMR - ) 2MSE (NMR - ) 2N5E (NMR - ) 3K2S (X-ray - ) 3R2P (X-ray 2.20A ) 4V6M (EM 7.10A ) 6CC9 (NMR - ) 6CCH (NMR - ) 6CCX (NMR - ) 6CLZ (NMR - ) 6CM1 (NMR - ) 6PTS (NMR - ) 6PTW (NMR - ) 6W4E (NMR - ) 6W4F (NMR - ) 7KJR (EM 2.08A ) 7RSC (NMR - ) 7RSE (NMR - ) |
| DBSNP | rs121912720 rs121912720 rs121912721 rs28929476 rs28931574 rs12718465 rs121912724 rs766422306 rs150243849 rs5077 rs921646982 rs4882 rs121912718 rs758509542 rs121912719 rs1015066427 rs121912727 rs5078 rs121912722 rs28931573 rs121912717 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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