| Gene Information | |
|---|---|
| Gene Name | APO2L |
| Organism | Homo sapiens (Human) |
| Gene Length | 281 |
| Protein Names | Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P50591 |
| Gene Card | TNFSF10 |
| Uniprot ID | P50591 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widespread; most predominant in spleen, lung and prostate. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.088483(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D0G (X-ray 2.40A ) 1D2Q (X-ray 2.80A ) 1D4V (X-ray 2.20A ) 1DG6 (X-ray 1.30A ) 1DU3 (X-ray 2.20A ) 4N90 (X-ray 3.30A ) 5CIR (X-ray 3.00A ) |
| DBSNP | rs6763816 rs16845759 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14609566}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:14609566}. Note=Exists both as membrane-bound and soluble form. {ECO:0000269|PubMed:14609566}. |
| Mouse PG classification | NA |
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