| Gene Information | |
|---|---|
| Gene Name | APLP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 650 |
| Protein Names | Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30] |
| Target Name | amyloid-like protein 1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000105290 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P51693 |
| Gene Card | APLP1 |
| Uniprot ID | P51693 |
| Pfam | PF10515; PF12924; PF12925; PF02177 |
| In ASD | no |
| Allosteric Prediction | yes (0.478457958) |
| Ortholog in Animals | Alpaca_ APLP1 ( ortholog_one2one ) Dog_ APLP1 ( ortholog_one2one ) GuineaPig_ APLP1 ( ortholog_one2one ) Macaque_ APLP1 ( ortholog_one2one ) Mouse_ Aplp1 ( ortholog_one2one ) Pig_ APLP1 ( ortholog_one2one ) Rat_ Aplp1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | APLP2, APP |
| Tissue | cerebral.cortex, brain |
| Tissue Specificity | Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). {ECO:0000269|PubMed:7494461}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3PMR (X-ray 2.11A ) 3Q7G (X-ray 2.30A ) 3Q7L (X-ray 2.20A ) 3QMK (X-ray 2.21A ) 4RD9 (X-ray 2.60A ) 4RDA (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein.; [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex. |
| Mouse PG classification | NA |
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