| Gene Information | |
|---|---|
| Gene Name | APLNR |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11) |
| Target Name | apelin receptor |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000134817 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P35414 |
| Gene Card | APLNR |
| Uniprot ID | P35414 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000096568) |
| Ortholog in Animals | Alpaca_ APLNR ( ortholog_one2one ) GuineaPig_ APLNR ( ortholog_one2one ) Macaque_ APLNR ( ortholog_one2one ) Mouse_ Aplnr ( ortholog_one2one ) Pig_ APLNR ( ortholog_one2one ) Rat_ Aplnr ( ortholog_one2one ) Rabbit_ APLNR ( ortholog_one2one ) |
| Ohnologs | CMKLR1, CXCR4 |
| Paralogs | AGTR2, AGTR1, GPR15, GPR25, RXFP4, BDKRB2, BDKRB1 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed:8294032, PubMed:25639753). Expressed in glial cells, astrocytes and neuronal subpopulations (PubMed:8294032). Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753). {ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:8294032}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LOT (NMR - ) 2LOU (NMR - ) 2LOV (NMR - ) 2LOW (NMR - ) 5VBL (X-ray 2.60A ) 6KNM (X-ray 3.20A ) 7SUS (X-ray 2.70A ) 7W0L (EM 3.57A ) 7W0M (EM 3.71A ) 7W0N (EM 4.21A ) 7W0O (EM 3.78A ) 7W0P (EM 3.16A ) |
| DBSNP | rs7943508 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:25639753}. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:25639753). {ECO:0000250|UniProtKB:Q9JHG3, ECO:0000269|PubMed:25639753}. |
| Mouse PG classification | NA |
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