| Gene Information | |
|---|---|
| Gene Name | API5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 524 |
| Protein Names | Apoptosis inhibitor 5 (API-5) (Antiapoptosis clone 11 protein) (AAC-11) (Cell migration-inducing gene 8 protein) (Fibroblast growth factor 2-interacting factor) (FIF) (Protein XAGL) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000166181 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZZ5 |
| Gene Card | API5 |
| Uniprot ID | Q9BZZ5 |
| Pfam | PF05918 |
| In ASD | no |
| Allosteric Prediction | no (-1.190322514) |
| Ortholog in Animals | Alpaca_ API5 ( ortholog_one2one ) Dog_ API5 ( ortholog_one2one ) Macaque_ API5 ( ortholog_one2one ) Mouse_ Api5 ( ortholog_one2one ) Pig_ API5 ( ortholog_one2one ) Rat_ Api5 ( ortholog_one2one ) Rabbit_ API5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:11075807, ECO:0000269|PubMed:11557113, ECO:0000269|PubMed:17827341, ECO:0000269|PubMed:19387494}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3U0R (X-ray 2.50A ) 3V6A (X-ray 2.60A ) 6L4O (X-ray 2.60A ) |
| DBSNP | rs5743240 rs2862934 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.; [Isoform 3]: Cytoplasm. |
| Mouse PG classification | NA |
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