| Gene Information | |
|---|---|
| Gene Name | TFR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 801 |
| Protein Names | Transferrin receptor protein 2 (TfR2) |
| Target Name | transferrin receptor |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106327 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9UP52 |
| Gene Card | TFR2 |
| Uniprot ID | Q9UP52 |
| Pfam | PF02225; PF04389 |
| In ASD | no |
| Allosteric Prediction | no (-0.039797511) |
| Ortholog in Animals | Alpaca_ TFR2 ( ortholog_one2many ) Dog_ TFR2 ( ortholog_one2one ) GuineaPig_ TFR2 ( ortholog_one2one ) Macaque_ TFR2 ( ortholog_one2one ) Mouse_ Tfr2 ( ortholog_one2one ) Pig_ TFR2 ( ortholog_one2one ) Rat_ Tfr2 ( ortholog_one2one ) |
| Ohnologs | TFRC |
| Paralogs | TFRC, NAALADL2, NAALAD2, FOLH1, NAALADL1 |
| Tissue | liver |
| Tissue Specificity | Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs80338876 rs80338879 rs41303465 rs34242818 rs41303501 rs80338889 rs41295942 |
| Subcellular location [CC] | Cell membrane; Single-pass type II membrane protein.; [Isoform Beta]: Cytoplasm {ECO:0000305}. Note=Lacks the transmembrane domain. Probably intracellular. |
| Mouse PG classification | HPG |
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