Gene Information
Gene NameAPG9L1
OrganismHomo sapiens (Human)
Gene Length839
Protein NamesAutophagy-related protein 9A (APG9-like 1) (mATG9)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ7Z3C6
Gene CardATG9A
Uniprot IDQ7Z3C6
PfamPF04109
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6WQZ  (EM  2.80A  )  6WR4  (EM  2.90A  )  7JLO  (EM  3.40A  )  7JLP  (EM  3.40A  )  7JLQ  (EM  4.00A  ) 
DBSNP rs2276635  rs2276634 
Subcellular location [CC]Preautophagosomal structure membrane {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:32073997, ECO:0000269|PubMed:33106659};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19910472};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:21068542, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:33468622, ECO:0000305|PubMed:34432599};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Late endosome membrane {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:32513819, ECO:0000269|PubMed:33468622};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Recycling endosome membrane {ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:29437695};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20124090, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665};
Multi-pass membrane protein {ECO:0000269|PubMed:32610138, ECO:0000269|PubMed:33106659}. Mitochondrion membrane {ECO:0000305|PubMed:34432599};
Multi-pass membrane protein {ECO:0000255}. Note=Mainly localizes to the trans-Golgi network (TGN) and the endosomal system;
cycles between them though vesicle trafficking (PubMed:27316455, PubMed:27663665). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427, PubMed:30262884). Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1 (PubMed:16940348). Upon autophagy induction, a small portion transiently localizes to the autophagic membranes (PubMed:22456507). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). {ECO:0000269|PubMed:16940348, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:27316455, ECO:0000269|PubMed:27663665, ECO:0000269|PubMed:29180427, ECO:0000269|PubMed:30262884, ECO:0000269|PubMed:34432599}.
Mouse PG classificationNA
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