| Gene Information | |
|---|---|
| Gene Name | APC |
| Organism | Homo sapiens (Human) |
| Gene Length | 2843 |
| Protein Names | Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000134982 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | APC |
| Uniprot ID | P25054 |
| Pfam | PF05972; PF05956; PF16689; PF05923; PF18797; PF00514; PF05937; PF05924 |
| In ASD | no |
| Allosteric Prediction | yes (0.486791381) |
| Ortholog in Animals | Alpaca_ APC ( ortholog_one2one ) Dog_ APC ( ortholog_one2one ) GuineaPig_ APC ( ortholog_one2one ) Macaque_ APC ( ortholog_one2one ) Mouse_ Apc ( ortholog_one2one ) Pig_ APC ( ortholog_one2one ) Rat_ Apc ( ortholog_one2one ) Rabbit_ APC ( ortholog_one2one ) |
| Ohnologs | APC2 |
| Paralogs | APC2 |
| Tissue | NA |
| Tissue Specificity | Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144). {ECO:0000269|PubMed:19527921, ECO:0000269|PubMed:21643010, ECO:0000269|PubMed:27217144}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.026415(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DEB (X-ray 2.40A ) 1EMU (X-ray 1.90A ) 1JPP (X-ray 3.10A ) 1M5I (X-ray 2.00A ) 1T08 (X-ray 2.10A ) 1TH1 (X-ray 2.50A ) 1V18 (X-ray 2.10A ) 2RQU (NMR - ) 3AU3 (X-ray 2.10A ) 3NMW (X-ray 1.60A ) 3NMX (X-ray 2.30A ) 3NMZ (X-ray 3.01A ) 3QHE (X-ray 2.40A ) 3RL7 (X-ray 2.30A ) 3RL8 (X-ray 2.20A ) 3T7U (X-ray 2.90A ) 4G69 (X-ray 2.00A ) 4YJE (X-ray 1.90A ) 4YJL (X-ray 2.10A ) 4YK6 (X-ray 1.70A ) 5B6G (X-ray 1.99A ) 5IZ6 (X-ray 2.15A ) 5IZ8 (X-ray 3.06A ) 5IZ9 (X-ray 2.93A ) 5IZA (X-ray 1.50A ) 5Z8H (X-ray 1.79A ) 7F6M (X-ray 2.40A ) 7F7O (X-ray 2.80A ) |
| DBSNP | rs139196838 rs137854567 rs33974176 rs1400295986 rs779998847 rs869312784 rs140493115 rs28933379 rs201830995 rs372481703 rs371113837 rs1291513037 rs770157475 rs1801155 rs863225349 rs1801166 rs137854578 rs878853445 rs2229996 rs459552 rs34157245 rs4987109 rs33941929 rs2229995 rs72541816 rs863224552 rs876658156 |
| Subcellular location [CC] | Cell junction, adherens junction {ECO:0000269|PubMed:16611247}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:20937854}. Cell projection, lamellipodium {ECO:0000269|PubMed:19151759}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19151759}. Cytoplasm {ECO:0000269|PubMed:10947987}. Cell membrane {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:16611247, ECO:0000269|PubMed:20937854}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). {ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:20937854}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |