| Gene Information | |
|---|---|
| Gene Name | APBB1IP |
| Organism | Homo sapiens (Human) |
| Gene Length | 666 |
| Protein Names | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1-interacting protein 1) (Proline-rich EVH1 ligand 1) (PREL-1) (Proline-rich protein 73) (Rap1-GTP-interacting adapter molecule) (RIAM) (Retinoic acid-responsive proline-rich protein 1) (RARP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000077420 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q7Z5R6 |
| Gene Card | APBB1IP |
| Uniprot ID | Q7Z5R6 |
| Pfam | PF00169; PF00788 |
| In ASD | no |
| Allosteric Prediction | no (-0.01148551) |
| Ortholog in Animals | Alpaca_ APBB1IP ( ortholog_one2one ) Dog_ APBB1IP ( ortholog_one2one ) GuineaPig_ APBB1IP ( ortholog_one2one ) Macaque_ APBB1IP ( ortholog_one2one ) Mouse_ Apbb1ip ( ortholog_one2one ) Pig_ APBB1IP ( ortholog_one2one ) Rat_ Apbb1ip ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | GRB7, RAPH1, GRB10, GRB14 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes. {ECO:0000269|PubMed:14530287, ECO:0000269|PubMed:15469846}. |
| Pharmacological Animal Models | 0.012880(Chimpanzee);0.001000(Mouse);0.001000(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2MWN (NMR - ) 3ZDL (X-ray 2.30A ) |
| DBSNP | rs34081356 rs7903226 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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