| Gene Information | |
|---|---|
| Gene Name | APAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1248 |
| Protein Names | Apoptotic protease-activating factor 1 (APAF-1) |
| Target Name | apoptotic protease-activating factor 1 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000120868 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O14727 |
| Gene Card | APAF1 |
| Uniprot ID | O14727 |
| Pfam | PF17908; PF00619; PF00931; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (0.339747187) |
| Ortholog in Animals | Alpaca_ APAF1 ( ortholog_one2one ) Dog_ APAF1 ( ortholog_one2one ) GuineaPig_ APAF1 ( ortholog_one2one ) Macaque_ APAF1 ( ortholog_one2one ) Mouse_ Apaf1 ( ortholog_one2one ) Pig_ APAF1 ( ortholog_one2one ) Rat_ Apaf1 ( ortholog_one2one ) Rabbit_ APAF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001375(Rat);0.100511(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1C15 (NMR - ) 1CWW (NMR - ) 1CY5 (X-ray 1.30A ) 1Z6T (X-ray 2.21A ) 2P1H (X-ray 1.59A ) 2YGS (X-ray 1.60A ) 3J2T (EM 9.50A ) 3JBT (EM 3.80A ) 3YGS (X-ray 2.50A ) 4RHW (X-ray 2.10A ) 5JUY (EM 4.10A ) 5WVC (X-ray 2.99A ) 5WVE (EM 4.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12804598}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |