| Gene Information | |
|---|---|
| Gene Name | AP4E1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1137 |
| Protein Names | AP-4 complex subunit epsilon-1 (AP-4 adaptor complex subunit epsilon) (Adaptor-related protein complex 4 subunit epsilon-1) (Epsilon subunit of AP-4) (Epsilon-adaptin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000081014 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UPM8 |
| Gene Card | AP4E1 |
| Uniprot ID | Q9UPM8 |
| Pfam | PF01602; PF14807 |
| In ASD | no |
| Allosteric Prediction | no (-0.878424188) |
| Ortholog in Animals | Alpaca_ AP4E1 ( ortholog_one2one ) Dog_ AP4E1 ( ortholog_one2one ) GuineaPig_ AP4E1 ( ortholog_one2one ) Macaque_ AP4E1 ( ortholog_one2one ) Mouse_ Ap4e1 ( ortholog_one2one ) Pig_ AP4E1 ( ortholog_one2one ) Rat_ Ap4e1 ( ortholog_one2one ) Rabbit_ AP4E1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AP2A1, AP1G2, AP1G1, AP2A2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10436028}. |
| Pharmacological Animal Models | 0.071326(Chimpanzee);0.071355(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs147005786 rs566579877 rs200034177 rs2306331 rs148499164 rs750328226 rs145541719 rs536656846 rs372479885 rs866266998 rs148817957 rs200678853 rs760021635 rs542940704 rs142215198 rs766696884 rs865868636 rs556450190 rs779094838 rs780520338 rs141278078 rs767423538 rs550237440 rs139640763 |
| Subcellular location [CC] | Golgi apparatus, trans-Golgi network membrane {ECO:0000305|PubMed:10436028}; Peripheral membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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