| Gene Information | |
|---|---|
| Gene Name | ACIN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1341 |
| Protein Names | Apoptotic chromatin condensation inducer in the nucleus (Acinus) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000100813 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UKV3 |
| Gene Card | ACIN1 |
| Uniprot ID | Q9UKV3 |
| Pfam | PF16294; PF02037 |
| In ASD | no |
| Allosteric Prediction | no (-0.999739168) |
| Ortholog in Animals | Alpaca_ ACIN1 ( ortholog_one2one ) Dog_ ACIN1 ( ortholog_one2one ) GuineaPig_ ACIN1 ( ortholog_one2one ) Macaque_ ACIN1 ( ortholog_one2one ) Mouse_ Acin1 ( ortholog_one2one ) Rat_ Acin1 ( ortholog_one2one ) Rabbit_ ACIN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001390(Rat);0.025(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6G6S (X-ray 1.65A ) |
| DBSNP | rs11555803 rs3811182 rs941719 rs1885097 rs3751501 rs754494408 |
| Subcellular location [CC] | Nucleus. Nucleus speckle. Nucleus, nucleoplasm. Note=Phosphorylation on Ser-1180 by SRPK2 redistributes it from the nuclear speckles to the nucleoplasm. |
| Mouse PG classification | NA |
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