| Gene Information | |
|---|---|
| Gene Name | AP2A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 939 |
| Protein Names | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000183020 ) 3 ( ENSG00000280759 ) 3 ( ENSG00000281385 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94973 |
| Gene Card | AP2A2 |
| Uniprot ID | O94973 |
| Pfam | PF01602; PF02296; PF02883 |
| In ASD | no |
| Allosteric Prediction | yes (0.80877496) |
| Ortholog in Animals | Alpaca_ AP2A2 ( ortholog_one2one ) Dog_ AP2A2 ( ortholog_one2one ) GuineaPig_ AP2A2 ( ortholog_one2one ) Macaque_ AP2A2 ( ortholog_one2one ) Mouse_ Ap2a2 ( ortholog_one2one ) Pig_ AP2A2 ( ortholog_one2one ) Rat_ Ap2a2 ( ortholog_one2one ) |
| Ohnologs | AP2A1 |
| Paralogs | AP2A1, AP1G2, AP1G1, AP4E1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the brain (at protein level). {ECO:0000269|PubMed:23676497}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.181902(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P17427}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17427}; Cytoplasmic side {ECO:0000250|UniProtKB:P17427}. Membrane, coated pit {ECO:0000250|UniProtKB:P17427}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17427}; Cytoplasmic side {ECO:0000250|UniProtKB:P17427}. Note=AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. {ECO:0000250|UniProtKB:P17427}. |
| Mouse PG classification | NA |
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