| Gene Information | |
|---|---|
| Gene Name | REPS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 660 |
| Protein Names | RalBP1-associated Eps domain-containing protein 2 (Partner of RalBP1) (RalBP1-interacting protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000169891 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NFH8 |
| Gene Card | REPS2 |
| Uniprot ID | Q8NFH8 |
| Pfam | PF12763 |
| In ASD | no |
| Allosteric Prediction | yes (0.167316025) |
| Ortholog in Animals | Alpaca_ REPS2 ( ortholog_one2one ) Dog_ REPS2 ( ortholog_one2one ) GuineaPig_ REPS2 ( ortholog_one2one ) Macaque_ REPS2 ( ortholog_one2one ) Mouse_ Reps2 ( ortholog_one2one ) Pig_ REPS2 ( ortholog_one2one ) Rat_ Reps2 ( ortholog_one2one ) Rabbit_ REPS2 ( ortholog_one2one ) |
| Ohnologs | REPS1 |
| Paralogs | EPS15L1, ITSN2, SRL, EPS15, ITSN1, EHD2, EHD4, EHD3, REPS1, EHD1 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in the cerebrum, cerebellum, lung, kidney, and testis. Weakly expressed in the kidney. Isoform 2 is down-regulated during progression of prostate cancer. {ECO:0000269|PubMed:12771942}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IQ3 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12771942}. |
| Mouse PG classification | NA |
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