Gene Information
Gene NameAP1G1
OrganismHomo sapiens (Human)
Gene Length822
Protein NamesAP-1 complex subunit gamma-1 (Adaptor protein complex AP-1 subunit gamma-1) (Adaptor-related protein complex 1 subunit gamma-1) (Clathrin assembly protein complex 1 gamma-1 large chain) (Gamma1-adaptin) (Golgi adaptor HA1/AP1 adaptin subunit gamma-1)
Target NameNA
Target TypeNA
Gene Age>4290 ( ENSG00000166747 )
Evolutionary StageEukaryota
AlphaFoldDBO43747
Gene CardAP1G1
Uniprot IDO43747
PfamPF01602; PF02883
In ASDno
Allosteric Predictionno (-0.808207085)
Ortholog in AnimalsAlpaca_ AP1G1 ( ortholog_one2one )
Dog_ PHLPP2 ( ortholog_one2one )
GuineaPig_ AP1G1 ( ortholog_one2one )
Macaque_ AP1G1 ( ortholog_one2one )
Mouse_ Ap1g1 ( ortholog_one2one )
Pig_ AP1G1 ( ortholog_one2one )
Rat_ Ap1g1 ( ortholog_one2one )
Rabbit_ AP1G1 ( ortholog_one2one )
OhnologsAP1G2
ParalogsAP1G2, AP2A1, AP2A2, AP4E1
TissueNA
Tissue SpecificityWidely expressed.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1IU1  (X-ray  1.80A  ) 
DBSNP rs36037071  rs904763 
Subcellular location [CC]Golgi apparatus {ECO:0000269|PubMed:12773381}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:12773381};
Peripheral membrane protein {ECO:0000269|PubMed:12773381};
Cytoplasmic side {ECO:0000269|PubMed:12773381}. Cytoplasm {ECO:0000269|PubMed:15758025}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025, ECO:0000269|PubMed:34102099}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:34102099}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (PubMed:12773381). Co-localizes with AFTPH/aftiphilin in the cytoplasm (PubMed:15758025). {ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:15758025}.
Mouse PG classificationNA
click here to return to the previous page