| Gene Information | |
|---|---|
| Gene Name | AOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1338 |
| Protein Names | Aldehyde oxidase (EC 1.2.3.1) (Aldehyde oxidase 1) (Azaheterocycle hydroxylase) (EC 1.17.3.-) |
| Target Name | aldehyde oxidase |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000138356 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q06278 |
| Gene Card | AOX1 |
| Uniprot ID | Q06278 |
| Pfam | PF01315; PF03450; PF00941; PF00111; PF01799; PF02738; PF20256 |
| In ASD | no |
| Allosteric Prediction | yes (0.572952139) |
| Ortholog in Animals | Alpaca_ AOX1 ( ortholog_one2one ) GuineaPig_ Aox1 ( ortholog_one2one ) Macaque_ AOX1 ( ortholog_one2one ) Mouse_ Aox1 ( ortholog_one2one ) Pig_ AOX1 ( ortholog_one2one ) Rat_ Aox1 ( ortholog_one2one ) Rabbit_ AOX1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XDH |
| Tissue | NA |
| Tissue Specificity | Abundant in liver, expressed in adipose tissue and at lower levels in lung, skeletal muscle, pancreas. In contrast to mice, no significant gender difference in AOX1 expression level (at protein level). {ECO:0000269|PubMed:18066686, ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:22031625, ECO:0000269|PubMed:22522748, ECO:0000269|PubMed:23857892, ECO:0000269|PubMed:8248161}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UHW (X-ray 2.60A ) 4UHX (X-ray 2.70A ) 5EPG (X-ray 3.39A ) 6Q6Q (X-ray 3.10A ) 7OPN (X-ray 2.60A ) 7ORC (X-ray 2.70A ) |
| DBSNP | rs58185012 rs41309768 rs56199635 rs55754655 rs141786030 rs3731722 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18671973, ECO:0000269|PubMed:20444863, ECO:0000269|PubMed:23857892}. |
| Mouse PG classification | NA |
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