| Gene Information | |
|---|---|
| Gene Name | AOC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | Membrane primary amine oxidase (EC 1.4.3.21) (Copper amine oxidase) (HPAO) (Semicarbazide-sensitive amine oxidase) (SSAO) (Vascular adhesion protein 1) (VAP-1) |
| Target Name | membrane copper amine oxidase |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000131471 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q16853 |
| Gene Card | AOC3 |
| Uniprot ID | Q16853 |
| Pfam | PF01179; PF02727; PF02728 |
| In ASD | no |
| Allosteric Prediction | yes (0.798684777) |
| Ortholog in Animals | Alpaca_ AOC3 ( ortholog_one2many ) Dog_ AOC3 ( ortholog_one2many ) GuineaPig_ AOC3 ( ortholog_one2one ) Mouse_ Aoc3 ( ortholog_one2one ) Rat_ Psme3 ( ortholog_one2one ) Rabbit_ AOC3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | AOC2, AOC1 |
| Tissue | NA |
| Tissue Specificity | Strongly expressed on the high endothelial venules of peripheral lymph nodes and on hepatic endothelia. Also highly expressed in appendix, lung and small intestine. Expressed also in adipose tissue, in bone marrow, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, spleen and testis. Isoform 2 seems to be the predominant transcript in fetal kidneys, fetal cartilage and fetal tonsils. The highest relative expression of isoform 2 occurs in skeletal muscle, heart, pancreas, kidney, and lung. {ECO:0000269|PubMed:17400359, ECO:0000269|PubMed:23349812, ECO:0000269|PubMed:9653080}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PU4 (X-ray 3.20A ) 1US1 (X-ray 2.90A ) 2C10 (X-ray 2.50A ) 2C11 (X-ray 2.90A ) 2Y73 (X-ray 2.60A ) 2Y74 (X-ray 2.95A ) 3ALA (X-ray 2.90A ) 4BTW (X-ray 2.80A ) 4BTX (X-ray 2.78A ) 4BTY (X-ray 3.10A ) |
| DBSNP | rs33954211 rs402680 rs2228470 rs408038 rs630079 rs438287 rs2229595 rs35097308 rs35643019 rs33986943 rs2229596 rs34987927 rs477207 rs34012919 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}. |
| Mouse PG classification | NA |
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