| Gene Information | |
|---|---|
| Gene Name | AOC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 751 |
| Protein Names | Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO) |
| Target Name | diamine oxidase |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000002726 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P19801 |
| Gene Card | AOC1 |
| Uniprot ID | P19801 |
| Pfam | PF01179; PF02727; PF02728 |
| In ASD | no |
| Allosteric Prediction | yes (0.829742525) |
| Ortholog in Animals | Alpaca_ AOC1 ( ortholog_one2many ) GuineaPig_ AOC1 ( ortholog_one2one ) Macaque_ AOC1 ( ortholog_one2one ) Mouse_ Aoc1l2 ( ortholog_one2many ) Mouse_ Aoc1l1 ( ortholog_one2many ) Mouse_ Aoc1 ( ortholog_one2many ) Mouse_ Aoc1l3 ( ortholog_one2many ) Pig_ AOC1 ( ortholog_one2one ) Rat_ Doxl2 ( ortholog_one2many ) Rat_ Svs1 ( ortholog_one2many ) Rat_ Aoc1 ( ortholog_one2many ) Rat_ Doxl1 ( ortholog_one2many ) Rabbit_ AOC1 ( ortholog_one2one ) |
| Ohnologs | AOC2 |
| Paralogs | AOC3, AOC2 |
| Tissue | small.intestine, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | Placenta and kidney. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3HI7 (X-ray 1.80A ) 3HIG (X-ray 2.09A ) 3HII (X-ray 2.15A ) 3K5T (X-ray 2.11A ) 3MPH (X-ray 2.05A ) |
| DBSNP | rs10156191 rs1049742 rs45558339 rs1049793 rs35070995 |
| Subcellular location [CC] | Secreted, extracellular space. |
| Mouse PG classification | NA |
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