Gene Information
Gene NameMAP4K1
OrganismHomo sapiens (Human)
Gene Length833
Protein NamesMitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Target Namemitogen-activated protein kinase kinase kinase kinase 1
Target TypeNA
Gene Age454 ( ENSG00000104814 )
3 ( ENSG00000282928 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ92918
Gene CardMAP4K1
Uniprot IDQ92918
PfamPF00780; PF00069
In ASDyes
Allosteric Predictionyes (1.000399465)
Ortholog in AnimalsAlpaca_ MAP4K1 ( ortholog_one2one )
Dog_ MAP4K1 ( ortholog_one2one )
GuineaPig_ MAP4K1 ( ortholog_one2one )
Macaque_ MAP4K1 ( ortholog_one2one )
Mouse_ Map4k1 ( ortholog_one2one )
Pig_ MAP4K1 ( ortholog_one2one )
Rat_ Map4k1 ( ortholog_one2one )
OhnologsMAP4K3, MAP4K5, MAP4K2
ParalogsPAK5, PAK6, PAK4, SBK2, STK39, PAK2, PAK1, PAK3, MINK1, TNIK, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4
Tissuespleen
Tissue SpecificityExpressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. {ECO:0000269|PubMed:8824585}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6CQD  (X-ray  2.12A  )  6CQE  (X-ray  1.89A  )  6CQF  (X-ray  2.25A  )  6NFY  (X-ray  2.17A  )  6NFZ  (X-ray  2.97A  )  6NG0  (X-ray  2.05A  )  7KAC  (X-ray  1.85A  )  7L24  (X-ray  2.68A  )  7L25  (X-ray  1.85A  )  7L26  (X-ray  2.30A  )  7M0K  (X-ray  2.01A  )  7M0L  (X-ray  2.43A  )  7M0M  (X-ray  1.93A  )  7R9L  (X-ray  2.33A  )  7R9N  (X-ray  1.50A  )  7R9P  (X-ray  2.27A  )  7R9T  (X-ray  2.00A  )  7SIU  (X-ray  1.79A  ) 
DBSNP rs55924696  rs34591617  rs56060067  rs1238066548  rs12975825 
Subcellular location [CC]NA
Mouse PG classificationNA
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