| Gene Information | |
|---|---|
| Gene Name | GRIN2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1464 |
| Protein Names | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) |
| Target Name | glutamate receptor ionotropic, nmda 2a |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000183454 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q12879 |
| Gene Card | GRIN2A |
| Uniprot ID | Q12879 |
| Pfam | PF01094; PF00060; PF10613; PF10565 |
| In ASD | yes |
| Allosteric Prediction | yes (1.728668711) |
| Ortholog in Animals | Alpaca_ GRIN2A ( ortholog_one2one ) Dog_ GRIN2A ( ortholog_one2one ) GuineaPig_ GRIN2A ( ortholog_one2one ) Macaque_ GRIN2A ( ortholog_one2one ) Mouse_ Grin2a ( ortholog_one2one ) Pig_ GRIN2A ( ortholog_one2one ) Rat_ Grin2a ( ortholog_one2one ) Rabbit_ GRIN2A ( ortholog_one2one ) |
| Ohnologs | GRIN2D, GRIN2C |
| Paralogs | GRIN3A, GRIK5, GRIN2C, GRID1, GRID2, GRIK3, GRIN2D, GRIN1, GRIK4, GRIA3, GRIK1, GRIA2, GRIA1, GRIN3B, GRIK2, GRIA4, GRIN2B |
| Tissue | brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.289107(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 3NFL (X-ray 1.91A ) 5H8F (X-ray 1.81A ) 5H8H (X-ray 2.23A ) 5H8N (X-ray 2.50A ) 5H8Q (X-ray 1.90A ) 5I2K (X-ray 2.86A ) 5I2N (X-ray 2.12A ) 5KCJ (X-ray 2.09A ) 5KDT (X-ray 2.44A ) 5TP9 (X-ray 2.40A ) 5TPA (X-ray 2.48A ) 6IRA (EM 4.50A ) 6IRF (EM 5.10A ) 6IRG (EM 5.50A ) 6IRH (EM 7.80A ) 7EOQ (EM 4.10A ) 7EOR (EM 4.00A ) 7EOS (EM 3.90A ) 7EOT (EM 3.80A ) 7EOU (EM 4.30A ) 7EU7 (EM 3.50A ) |
| DBSNP | rs1250662891 rs587780353 rs1377082706 rs868215122 rs148531310 rs199528312 rs568484876 rs148511104 rs761168789 rs149344082 rs1057519551 rs1555496111 rs139033056 rs145956175 rs1360906241 rs796052543 rs397518470 rs397518468 rs397518450 rs551688681 rs397518447 rs397514557 rs397518471 rs796052548 rs1555491648 rs143031592 rs1057519552 rs762659685 rs1555488144 rs796052549 rs780654733 rs796052551 rs150316865 rs777684328 rs1555482933 rs200037904 rs767268773 rs933322445 rs769602505 rs765370528 rs886039239 rs531782747 rs1258974659 rs138809301 rs867432846 rs267604687 rs867464241 rs747136651 rs145063086 rs367543132 rs774419037 rs976259560 rs138415164 |
| Subcellular location [CC] | Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q00959}. Cell membrane {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000250|UniProtKB:P35436}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q00959}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436}. |
| Mouse PG classification | NA |
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