Gene Information
Gene NameITGB4
OrganismHomo sapiens (Human)
Gene Length1822
Protein NamesIntegrin beta-4 (GP150) (CD antigen CD104)
Target Nameintegrin beta-4
Target TypeNA
Gene Age680 ( ENSG00000132470 )
Evolutionary StageEumetazoa
AlphaFoldDBP16144
Gene CardITGB4
Uniprot IDP16144
PfamPF03160; PF07974; PF00041; PF18372; PF07965; PF00362; PF17205
In ASDno
Allosteric Predictionyes (0.274646374)
Ortholog in AnimalsAlpaca_ ITGB4 ( ortholog_one2one )
Dog_ ITGB4 ( ortholog_one2one )
GuineaPig_ ITGB4 ( ortholog_one2one )
Macaque_ ITGB4 ( ortholog_one2one )
Mouse_ Itgb4 ( ortholog_one2one )
Pig_ ITGB4 ( ortholog_one2one )
Rat_ Itgb4 ( ortholog_one2one )
Rabbit_ ITGB4 ( ortholog_one2one )
OhnologsNA
ParalogsITGB7, ITGB3, ITGB5, ITGB8, ITGB6, ITGB1, ITGB2, ITGBL1
TissueNA
Tissue SpecificityIntegrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1QG3  (X-ray  2.15A  )  2YRZ  (NMR  -  )  3F7P  (X-ray  2.75A  )  3F7Q  (X-ray  1.75A  )  3F7R  (X-ray  2.04A  )  3FQ4  (X-ray  1.49A  )  3FSO  (X-ray  1.41A  )  3H6A  (X-ray  1.61A  )  4Q58  (X-ray  4.00A  )  4WTW  (X-ray  1.61A  )  4WTX  (X-ray  1.50A  )  6GVK  (X-ray  1.55A  )  6GVL  (X-ray  2.05A  ) 
DBSNP rs121912465  rs80338755  rs143114124  rs121912461  rs201494421  rs1476568580  rs1422797135  rs1304888529  rs8079267  rs121912463  rs140819116  rs121912466  rs149284152  rs121912468  rs121912467  rs1051486  rs871443 
Subcellular location [CC]Cell membrane;
Single-pass type I membrane protein. Cell membrane;
Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes.
Mouse PG classificationHPG
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