Gene Information
Gene NameUBE3A
OrganismHomo sapiens (Human)
Gene Length875
Protein NamesUbiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000114062 )
Evolutionary StageEukaryota
AlphaFoldDBQ05086
Gene CardUBE3A
Uniprot IDQ05086
PfamPF16558; PF00632
In ASDno
Allosteric Predictionyes (0.219249852)
Ortholog in AnimalsAlpaca_ UBE3A ( ortholog_one2one )
Dog_ UBE3A ( ortholog_one2one )
GuineaPig_ UBE3A ( ortholog_one2one )
Macaque_ UBE3A ( ortholog_one2one )
Mouse_ Ube3a ( ortholog_one2one )
Pig_ UBE3A ( ortholog_one2one )
Rat_ Ube3a ( ortholog_one2one )
Rabbit_ UBE3A ( ortholog_one2one )
OhnologsHECTD2
ParalogsHERC4, NEDD4, HECTD1, NEDD4L, UBE3B, HUWE1, SMURF1, AREL1, UBR5, HERC2, HECW2, HERC3, WWP1, UBE3C, SMURF2, HACE1, HECTD2, HECTD4, ITCH, HECW1, WWP2, TRIP12, HERC5, HERC6
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1C4Z  (X-ray  2.60A  )  1D5F  (X-ray  2.80A  )  1EQX  (NMR  -  )  2KR1  (NMR  -  )  4GIZ  (X-ray  2.55A  )  4XR8  (X-ray  2.25A  )  6SJV  (X-ray  2.03A  )  6SLM  (X-ray  2.80A  )  6TGK  (X-ray  1.30A  )  6U19  (NMR  -  ) 
DBSNP rs587784511  rs587781241  rs587782907  rs587782915  rs147145506  rs587780581  rs587780582  rs587780583  rs1059383  rs587782908  rs141984760  rs587781242  rs587780584  rs587781243  rs587782916  rs587781233  rs587781244  rs587781235  rs587782918  rs587782919  rs587781236  rs587782920  rs587781237  rs587782910  rs587781239 
Subcellular location [CC]Cytoplasm {ECO:0000250|UniProtKB:O08759}. Nucleus {ECO:0000250|UniProtKB:O08759}.
Mouse PG classificationLPG
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