Gene Information
Gene NameRAB7A
OrganismHomo sapiens (Human)
Gene Length207
Protein NamesRas-related protein Rab-7a (EC 3.6.5.2)
Target Nameras-related protein rab-7a
Target TypeNA
Gene Age1488 ( ENSG00000075785 )
Evolutionary StageEukaryota
AlphaFoldDBP51149
Gene CardRAB7A
Uniprot IDP51149
PfamPF00071
In ASDno
Allosteric Predictionyes (0.057710061)
Ortholog in AnimalsAlpaca_ RAB7A ( ortholog_one2one )
Dog_ RAB7A ( ortholog_one2one )
GuineaPig_ RAB7A ( ortholog_one2one )
Macaque_ RAB7A ( ortholog_one2one )
Mouse_ Rab7 ( ortholog_one2one )
Pig_ RAB7A ( ortholog_one2one )
Rat_ Rab7a ( ortholog_one2one )
OhnologsNA
ParalogsRAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27
TissueNA
Tissue SpecificityWidely expressed;
high expression found in skeletal muscle. {ECO:0000269|PubMed:12545426}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.152814(Rat);0.097414(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1T91  (X-ray  1.90A  )  1YHN  (X-ray  3.00A  )  3LAW  (X-ray  2.80A  )  6IYB  (X-ray  2.09A  )  6WCW  (X-ray  2.80A  )  7F6J  (X-ray  2.10A  ) 
DBSNP rs11549759  rs121909078  rs121909081  rs121909080  rs121909079 
Subcellular location [CC]Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:28325809};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:20028791};
Peripheral membrane protein {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Lipid droplet {ECO:0000250|UniProtKB:P51150}. Endosome membrane {ECO:0000269|PubMed:22431521};
Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P51150}. Mitochondrion membrane {ECO:0000305|PubMed:34432599};
Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (PubMed:21255211). Lipid droplet localization is increased upon ADRB2 stimulation (By similarity). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:34432599}.
Mouse PG classificationLPG
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