| Gene Information | |
|---|---|
| Gene Name | ANKS1B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1248 |
| Protein Names | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000185046 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z6G8 |
| Gene Card | ANKS1B |
| Uniprot ID | Q7Z6G8 |
| Pfam | PF12796; PF00640; PF00536 |
| In ASD | no |
| Allosteric Prediction | no (-0.670016808) |
| Ortholog in Animals | Alpaca_ ANKS1B ( ortholog_one2one ) GuineaPig_ ANKS1B ( ortholog_one2one ) Macaque_ ANKS1B ( ortholog_one2one ) Mouse_ Anks1b ( ortholog_one2one ) Pig_ ANKS1B ( ortholog_one2one ) Rat_ Anks1b ( ortholog_one2one ) Rabbit_ ANKS1B ( ortholog_one2one ) |
| Ohnologs | ANKS1A |
| Paralogs | ANKS1A |
| Tissue | cerebral.cortex |
| Tissue Specificity | Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. {ECO:0000269|PubMed:10490826, ECO:0000269|PubMed:15347684}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2EAM (NMR - ) 2KE7 (NMR - ) 2KIV (NMR - ) 2M38 (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15004329, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129, ECO:0000269|PubMed:19666031}.; [Isoform 2]: Nucleus.; [Isoform 3]: Postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. Note=The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). {ECO:0000250}.; [Isoform 4]: Nucleus. Note=The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus. |
| Mouse PG classification | NA |
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