| Gene Information | |
|---|---|
| Gene Name | MMP21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 390 |
| Protein Names | Matrix metalloproteinase-23 (MMP-23) (EC 3.4.24.-) (Femalysin) (MIFR-1) (Matrix metalloproteinase-21) (MMP-21) (Matrix metalloproteinase-22) (MMP-22) [Cleaved into: Matrix metalloproteinase-23, soluble form] |
| Target Name | matrix metalloproteinase-21 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000154485 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75900 |
| Gene Card | MMP23B |
| Uniprot ID | O75900 |
| Pfam | PF00413; PF01549 |
| In ASD | no |
| Allosteric Prediction | no (-0.968816366) |
| Ortholog in Animals | Alpaca_ MMP21 ( ortholog_one2one ) Dog_ MMP21 ( ortholog_one2one ) GuineaPig_ MMP21 ( ortholog_one2one ) Macaque_ MMP21 ( ortholog_one2one ) Mouse_ Mmp21 ( ortholog_one2one ) Rat_ Mmp21 ( ortholog_one2one ) Rabbit_ MMP21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MMP24, MMP16, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in ovary, testis and prostate. {ECO:0000269|PubMed:9988691}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:11328856}; Single-pass type II membrane protein {ECO:0000269|PubMed:11328856}. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}. |
| Mouse PG classification | HPG |
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