| Gene Information | |
|---|---|
| Gene Name | PPFIA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1194 |
| Protein Names | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000177380 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75145 |
| Gene Card | PPFIA3 |
| Uniprot ID | O75145 |
| Pfam | PF00536; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.44382912) |
| Ortholog in Animals | Alpaca_ PPFIA3 ( ortholog_one2one ) Dog_ PPFIA3 ( ortholog_one2one ) GuineaPig_ PPFIA3 ( ortholog_one2one ) Macaque_ PPFIA3 ( ortholog_one2one ) Mouse_ Ppfia3 ( ortholog_one2one ) Pig_ PPFIA3 ( ortholog_one2one ) Rat_ Ppfia3 ( ortholog_one2one ) |
| Ohnologs | PPFIA1, PPFIA2, PPFIA4 |
| Paralogs | PPFIBP1, PPFIBP2, PPFIA1, PPFIA2, PPFIA4 |
| Tissue | brain, skin, cerebral.cortex |
| Tissue Specificity | Predominantly expressed in brain (PubMed:9624153). Also detected in sperm (at protein level) (PubMed:23124857). {ECO:0000269|PubMed:23124857, ECO:0000269|PubMed:9624153}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2303053 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q91Z79}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:23124857}. Note=Also detected in epididymosome. {ECO:0000250|UniProtKB:Q91Z79}. |
| Mouse PG classification | NA |
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