| Gene Information | |
|---|---|
| Gene Name | SLC6A7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 636 |
| Protein Names | Sodium-dependent proline transporter (Solute carrier family 6 member 7) |
| Target Name | sodium-dependent proline transporter |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000011083 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q99884 |
| Gene Card | SLC6A7 |
| Uniprot ID | Q99884 |
| Pfam | PF00209 |
| In ASD | no |
| Allosteric Prediction | no (-0.212470233) |
| Ortholog in Animals | Alpaca_ SLC6A7 ( ortholog_one2one ) Dog_ SLC6A7 ( ortholog_one2one ) GuineaPig_ SLC6A7 ( ortholog_one2one ) Macaque_ SLC6A7 ( ortholog_one2one ) Mouse_ Slc6a7 ( ortholog_one2one ) Pig_ SLC6A7 ( ortholog_one2one ) Rat_ Slc6a7 ( ortholog_one2one ) Rabbit_ SLC6A7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC6A20, SLC6A9, SLC6A2, SLC6A18, SLC6A4, SLC6A16, SLC6A8, SLC6A5, SLC6A14, SLC6A6, SLC6A15, SLC6A13, SLC6A11, SLC6A19, SLC6A1, SLC6A17, SLC6A12, SLC6A3 |
| Tissue | amygdala, brain, brain.meninx, cerebellum, hippocampus, locus.ceruleus, middle.frontal.gyrus, middle.temporal.gyrus, occipital.cortex, occipital.lobe, olfactory.apparatus, parietal.lobe, thalamus, cerebellar.hemisphere |
| Tissue Specificity | Brain specific (at protein level) (PubMed:7651355). Highly expressed in hippocampus, corpus striatum and temporal cortex. Also expressed in frontal cortex, occipital cortex and, at lower levels, in cerebellum and parietal cortex (at protein level) (PubMed:7651355). {ECO:0000269|PubMed:7651355}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1468564 |
| Subcellular location [CC] | Synaptic cell membrane {ECO:0000269|PubMed:7651355}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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