Gene Information
Gene NameCACNA1C
OrganismHomo sapiens (Human)
Gene Length2221
Protein NamesVoltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
Target Namevoltage-dependent l-type calcium channel subunit alpha-1c
Target TypeNA
Gene Age645 ( ENSG00000151067 )
3 ( ENSG00000285479 )
Evolutionary StageEukaryota
AlphaFoldDBQ13936
Gene CardCACNA1C
Uniprot IDQ13936
PfamPF08763; PF16885; PF16905; PF00520
In ASDyes
Allosteric Predictionyes (1.661245598)
Ortholog in AnimalsAlpaca_ CACNA1C ( ortholog_one2one )
GuineaPig_ CACNA1C ( ortholog_one2one )
Macaque_ CACNA1C ( ortholog_one2one )
Mouse_ Cacna1c ( ortholog_one2one )
Pig_ CACNA1C ( ortholog_one2one )
Rat_ Cacna1c ( ortholog_one2one )
Rabbit_ CACNA1C ( ortholog_one2one )
OhnologsCACNA1F, CACNA1S, CACNA1D
ParalogsSCN11A, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
TissueNA
Tissue SpecificityDetected throughout the brain, including hippocampus, cerebellum and amygdala, throughout the heart and vascular system, including ductus arteriosus, in urinary bladder, and in retina and sclera in the eye (PubMed:15454078). Expressed in brain, heart, jejunum, ovary, pancreatic beta-cells and vascular smooth muscle. Overall expression is reduced in atherosclerotic vascular smooth muscle. {ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:8392192}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1T0J  (X-ray  2.00A  )  2BE6  (X-ray  2.00A  )  2F3Y  (X-ray  1.45A  )  2F3Z  (X-ray  1.60A  )  2LQC  (NMR  -  )  3G43  (X-ray  2.10A  )  3OXQ  (X-ray  2.55A  )  5V2P  (X-ray  2.00A  )  5V2Q  (X-ray  1.70A  )  6C0A  (NMR  -  )  6DAD  (X-ray  1.65A  )  6DAE  (X-ray  2.00A  )  6DAF  (X-ray  2.40A  )  6U39  (X-ray  2.40A  )  6U3A  (X-ray  1.65A  )  6U3B  (X-ray  1.70A  )  6U3D  (X-ray  1.75A  )  7L8V  (NMR  -  ) 
DBSNP rs1051345  rs1051356  rs10848683  rs10774053  rs10774054  rs112414325  rs771424529  rs549476254 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315};
Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15381};
Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P22002}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P22002}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22002}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q01815}. Note=Colocalizes with ryanodine receptors in distinct clusters at the junctional membrane, where the sarcolemma and the sarcoplasmic reticulum are in close contact. The interaction between RRAD and CACNB2 promotes the expression of CACNA1C at the cell membrane. {ECO:0000250|UniProtKB:P15381}.
Mouse PG classificationNA
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