| Gene Information | |
|---|---|
| Gene Name | ANGPT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 496 |
| Protein Names | Angiopoietin-2 (ANG-2) |
| Target Name | angiopoietin-2 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000091879 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O15123 |
| Gene Card | ANGPT2 |
| Uniprot ID | O15123 |
| Pfam | PF00147 |
| In ASD | no |
| Allosteric Prediction | yes (0.703980977) |
| Ortholog in Animals | Alpaca_ ANGPT2 ( ortholog_one2one ) Dog_ ANGPT2 ( ortholog_one2one ) GuineaPig_ ANGPT2 ( ortholog_one2one ) Macaque_ ANGPT2 ( ortholog_one2one ) Mouse_ Angpt2 ( ortholog_one2one ) Pig_ ANGPT2 ( ortholog_one2one ) Rat_ Angpt2 ( ortholog_one2one ) Rabbit_ ANGPT2 ( ortholog_one2one ) |
| Ohnologs | ANGPT1 |
| Paralogs | TNC, FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, TNN, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FCN3, FNDC7, FGL2, FGG, ANGPT1, FN1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z3S (X-ray 2.35A ) 1Z3U (X-ray 2.25A ) 2GY7 (X-ray 3.70A ) 4JZC (X-ray 1.90A ) 4ZFG (X-ray 2.27A ) |
| DBSNP | rs61733318 rs767462360 rs7813215 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:32908006}. |
| Mouse PG classification | NA |
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