| Gene Information | |
|---|---|
| Gene Name | IFNAR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 515 |
| Protein Names | Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2) |
| Target Name | interferon alpha/beta receptor 2 |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000159110 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P48551 |
| Gene Card | IFNAR2 |
| Uniprot ID | P48551 |
| Pfam | PF09294; PF01108 |
| In ASD | no |
| Allosteric Prediction | yes (0.299402304) |
| Ortholog in Animals | Alpaca_ IFNAR2 ( ortholog_one2many ) Dog_ IFNAR2 ( ortholog_one2one ) Macaque_ IFNAR2 ( ortholog_one2one ) Mouse_ Ifnar2 ( ortholog_one2one ) Pig_ IFNAR2 ( ortholog_one2one ) Rat_ Ifnar2 ( ortholog_one2one ) Rabbit_ IFNAR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IFNAR1, IL22RA2, IFNGR2, IL22RA1, F3, IFNLR1, IL10RA, IL20RB, IL20RA, IFNGR1, IL10RB |
| Tissue | NA |
| Tissue Specificity | Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. {ECO:0000269|PubMed:7588638, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}. |
| Pharmacological Animal Models | 0.022255(Chimpanzee);0.025650(Mouse);0.002808(Rat);0.071429(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1N6U (NMR - ) 1N6V (NMR - ) 2HYM (NMR - ) 2KZ1 (NMR - ) 2LAG (NMR - ) 3S8W (X-ray 2.60A ) 3S9D (X-ray 2.00A ) 3SE3 (X-ray 4.00A ) 3SE4 (X-ray 3.50A ) |
| DBSNP | rs2229207 rs1051393 rs201003373 rs142850110 rs17860223 rs747605798 rs763508005 rs759744926 rs756571542 rs201411274 rs148519830 rs1441207963 rs1231284605 rs866733383 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:7665574}; Single-pass type I membrane protein {ECO:0000269|PubMed:7665574}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}; Single-pass type I membrane protein {ECO:0000269|PubMed:7665574}.; [Isoform 3]: Secreted {ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059}. |
| Mouse PG classification | NA |
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