| Gene Information | |
|---|---|
| Gene Name | SLC39A4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 647 |
| Protein Names | Zinc transporter ZIP4 (Solute carrier family 39 member 4) (Zrt- and Irt-like protein 4) (ZIP-4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000147804 ) 3 ( ENSG00000285243 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q6P5W5 |
| Gene Card | SLC39A4 |
| Uniprot ID | Q6P5W5 |
| Pfam | PF02535; PF18292 |
| In ASD | yes |
| Allosteric Prediction | no (-0.370172392) |
| Ortholog in Animals | Alpaca_ SLC39A4 ( ortholog_one2many ) Dog_ SLC39A4 ( ortholog_one2one ) GuineaPig_ SLC39A4 ( ortholog_one2one ) Macaque_ SLC39A4 ( ortholog_one2one ) Mouse_ Slc39a4 ( ortholog_one2one ) Pig_ SLC39A4 ( ortholog_one2one ) Rat_ Slc39a4 ( ortholog_one2one ) |
| Ohnologs | SLC39A12 |
| Paralogs | SLC39A6, SLC39A8, SLC39A5, SLC39A10, SLC39A12, SLC39A14 |
| Tissue | duodenum, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum. {ECO:0000269|PubMed:12032886, ECO:0000269|PubMed:12068297}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2280839 rs2280838 rs117535951 rs121434292 rs121434290 rs17855765 rs1871533 rs121434287 rs2977838 rs7823979 rs121434293 rs782110796 rs121434291 rs2272662 rs1871534 rs121434289 rs121434288 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000269|PubMed:14612438}. Recycling endosome membrane {ECO:0000269|PubMed:14612438}; Multi-pass membrane protein {ECO:0000269|PubMed:14612438}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. |
| Mouse PG classification | LPG |
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