| Gene Information | |
|---|---|
| Gene Name | AMY2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 511 |
| Protein Names | Pancreatic alpha-amylase (PA) (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) |
| Target Name | pancreatic alpha-amylase |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000243480 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P04746 |
| Gene Card | AMY2A |
| Uniprot ID | P04746 |
| Pfam | PF00128; PF02806 |
| In ASD | yes |
| Allosteric Prediction | yes (0.844665657) |
| Ortholog in Animals | Alpaca_ AMY2A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SLC3A1, SLC3A2, GBE1, AMY2B, AMY1C, AMY1B, AMY1A |
| Tissue | pancreas, parotid.gland |
| Tissue Specificity | Detected in pancreas (at protein level). {ECO:0000269|PubMed:8528071}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B2Y (X-ray 3.20A ) 1BSI (X-ray 2.00A ) 1CPU (X-ray 2.00A ) 1HNY (X-ray 1.80A ) 1KB3 (X-ray 2.10A ) 1KBB (X-ray 1.90A ) 1KBK (X-ray 1.90A ) 1KGU (X-ray 2.00A ) 1KGW (X-ray 2.10A ) 1KGX (X-ray 2.00A ) 1U2Y (X-ray 1.95A ) 1U30 (X-ray 1.90A ) 1U33 (X-ray 1.95A ) 1XCW (X-ray 2.00A ) 1XCX (X-ray 1.90A ) 1XD0 (X-ray 2.00A ) 1XD1 (X-ray 2.20A ) 1XGZ (X-ray 2.00A ) 1XH0 (X-ray 2.00A ) 1XH1 (X-ray 2.03A ) 1XH2 (X-ray 2.20A ) 2CPU (X-ray 2.00A ) 2QMK (X-ray 2.30A ) 2QV4 (X-ray 1.97A ) 3BAI (X-ray 1.90A ) 3BAJ (X-ray 2.10A ) 3BAK (X-ray 1.90A ) 3BAW (X-ray 2.00A ) 3BAX (X-ray 1.90A ) 3BAY (X-ray 1.99A ) 3CPU (X-ray 2.00A ) 3IJ7 (X-ray 2.00A ) 3IJ8 (X-ray 1.43A ) 3IJ9 (X-ray 1.85A ) 3OLD (X-ray 2.00A ) 3OLE (X-ray 1.55A ) 3OLG (X-ray 2.30A ) 3OLI (X-ray 1.50A ) 4GQQ (X-ray 1.35A ) 4GQR (X-ray 1.20A ) 4W93 (X-ray 1.35A ) 4X9Y (X-ray 1.07A ) 5E0F (X-ray 1.40A ) 5EMY (X-ray 1.23A ) 5KEZ (X-ray 1.83A ) 5TD4 (X-ray 2.30A ) 5U3A (X-ray 0.95A ) 5VA9 (X-ray 2.55A ) 6OBX (X-ray 1.30A ) 6OCN (X-ray 1.15A ) 6Z8L (X-ray 1.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted, extracellular space. |
| Mouse PG classification | NA |
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